The development of physical and computational mechanisms aimed at augmenting architectural environments has been one of the foci of research implemented at the Faculty of Architecture and the Built Environment, Delft University of Technology (TUD) for more than a decade. This paper presents the integration of distributed responsive climate control into the built environment based on Design-to-Robotic-Production and -Operation (D2RP&O) principles. These connect computational design with robotic production and operation of buildings. In the presented case study structural elements meet load-bearing as well as functional requirements. Their spatial arrangement creates variable densities for accommodating sensor-actuators that are operating heating and cooling. This mechatronic operation relies on activity recognition for achieving responsive climate control in the built-environment.